Relapsing Fever Borreliosis in IL-10 Deficient Mice
نویسندگان
چکیده
* Corresponding author: Dr. Diego Cadavid, Center for Immunity and Inflammatory Diseases, 16 Massachusetts General Hospital, 149 13 th Street, Room 8301, Charlestown, MA 02129 17 Phone 617-6793680; fax 617-6793518; email: [email protected] 18 19 AC CE PT ED Copyright © 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. Infect. Immun. doi:10.1128/IAI.00587-08 IAI Accepts, published online ahead of print on 15 September 2008
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IL-10 helps control pathogen load during high-level bacteremia.
During relapsing fever borreliosis, a high pathogen load in the blood occurs at times of peak bacteremia. Specific IgM Abs are responsible for spirochetal clearance so in absence of B cells there is persistent high-level bacteremia. Previously, we showed that B cell-deficient mice persistently infected with Borrelia turicatae produce high levels of IL-10 and that exogenous IL-10 reduces bactere...
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تاریخ انتشار 2008